gru NURSES RESPOSIBILITY | Instruct patient to take acamprosate exactlyas prescribed, even if a relapse occurs,and to seek help for a relapse.•Warn patient that acamprosate won’treduce symptoms of alcohol withdrawal ifrelapse occurs followed by cessation.• Urge caregivers to monitor patient for evidenceof depression (lack of appetite orinterest in life, fatigue, excessive sleeping,difficulty concentrating) or suicidal tendenciesbecause a small number ofpatients taking acamprosate have attemptedsuicide.• Advise patient to use caution when performinghazardous activities until adverseCNS effects of drug are known. |
SIDE EFFECTS | Adverse ReactionsCNS: Abnormal thinking, amnesia, ...view middle of the document...
By interacting withGABA receptor sites, acamprosate preventsGABA from bindingWhen glutamate binds to its receptors, itcloses the chloride ion channel, increasingneuronal excitability by promotingdepolarization (below left). This imbalancefosters a craving for alcohol. Byinteracting with glutamate receptor sites,acamprosate prevents glutamate frombinding |
FREQUENCY | TID |
ROUTE | Oral |
DOSE | Adults. 666 m |
DRUG NAME | acamprosatecalcium |
NURSES RESPOSIBILITY | Check apical and radial pulses before givingacebutolol. Also, frequently monitorblood pressure and pulse rate, rhythm,and quality during treatment.• Give drug with food to prevent GI upset.• Acebutolol may elevate uric acid, potassium,triglyceride, lipoprotein, and antinuclearantibody levels; it also may interferewith accuracy of glucose tolerance tests.•Monitor diabetic patient’s blood glucoselevel to spot alterations.• Notify prescriber if you detect a heart ratebelow 50 beats/min or signs of heart failure,such as dyspnea, crackles, unexplainedweight gain, and jugular vein distention.•Monitor patient for peripheral edema, andevaluate fluid intake and output. |
SIDE EFFECTS | CNS: Abnormal dreams, anxiety, confusion,depression, dizziness, fatigue, fever, headache,insomniaCV: Bradycardia, chest pain, edema, heartblock, heart failure, hypotensionEENT: Abnormal vision, conjunctivitis, dryeyes, eye pain, pharyngitis, rhinitisGI: Constipation, diarrhea, flatulence,hepatotoxicity, indigestion, nauseaGU: Dysuria, impotence, polyuriaMS: Arthralgia, myalgiaRESP: Bronchospasm, cough, dyspnea,wheezingSKIN: Rash |
INDICATION | To treat hypertensionMechanism of ActionInhibits stimulation of beta1 receptors inthe heart, decreasing cardiac excitability,heart rate, cardiac output, and myocardialoxygen demand. Acebutolol also decreaseskidneys’ release of renin, which helpsreduce blood pressure. Drug suppresses SAnode automaticity and AV node conductivity,which suppresses atrial and ventricularectopy. By decreasing myocardial oxygendemand, acebutolol decreases myocardialischemia. At high doses, it inhibits stimula- tion of beta2 receptors in the lungs and maycause bronchoconstriction.CONTRAINDICATIONCardiogenic shock, heart failure unlessfrom tachyarrhythmia, hypersensitivity toacebutolol, overt heart failure, second- andthird-degree heart block, severe bradycardia |
ACTION | Therapeutic class: Antihypertensive, class IIantiarrhythmic |
FREQUENCY | BD |
ROUTE | oral |
DOSE | Initial: 200 mg b.i.d. Usual: 600 to1,200 mg daily |
DRUG NAME | acebutololhydrochloride |
NURSES RESPOSIBILITY | Before and during long-term therapy,monitor liver function test results, includingAST, ALT, bilirubin, and creatinine levels,as ordered.•Monitor renal function in patient on longtermtherapy. Keep in mind that blood oralbumin in urine may indicate nephritis;decreased urine output may indicate renal failure; and dark brown urine may indicatepresence of the...